Clinical Resources
PONS Presentation: Alteplase for Acute Ischemic Stroke - Updates & Issues (No CEU)
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The criteria used to select patients for alteplase therapy in acute ischemic stroke has been recently reviewed and
updated based on available data and expert opinion. Many of the restrictions for alteplase use have been revised to
allow more potential patients to receive the benefits of thrombolysis while still maintaining overall safety. This
presentation reviews several of these updates as well as review clinical implications of dosing issues that may be
encountered when using alteplase. The use of intra-arterial alteplase for targeted treatment of stroke is also discussed
and compared to the intravenous route. Finally, a discussion of two adverse effects from alteplase – intracranial
hemorrhage and angioedema – outlines management strategies.
Presentation Objectives:
- Discuss updates to the eligibility criteria for alteplase in acute ischemic stroke
- Describe the role of intra-arterial alteplase therapy in acute ischemic stroke patients
- Evaluate challenges encountered during alteplase administration